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Center for Addiction & Disease Risk Exacerbation

Carolina Haass-Koffler, Ph.D.

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  • Lauren Micalizzi, Ph.D. & Rachel Gunn, Ph.D.
  • Erica Eaton, Ph.D. & Christy Capone, Ph.D.
  • Tim Janssen, Ph.D.
  • Carolina Haass-Koffler, Ph.D.
  • Cara Murphy, Ph.D.
  • Alexander Sokolovsky, Ph.D.

Carolina Haass-Koffler, Ph.D.

Oxytocin to Reduce Stress-Induced Craving in Patients with Opioid Use Disorder

Project Leader

  • carolina haass-koffler

    Carolina Haass-Koffler, PharmD, Ph.D.

    Fmr. Pilot Project Lead, Associate Professor of Psychiatry and Human Behavior, Associate Professor of Behavioral and Social Sciences
    carolina_haass-koffler@brown.edu
    Research Profile

Project Status: 

Dr. Haass-Koffler graduated as CADRE Pilot Project Lead after receiving an R01 in 2022.

Description:

Dr. Haass-Koffler’s project integrated a pharmacological therapy (i.e., oxytocin administration) with a cue-reactivity paradigm and the administration of yohimbine, an α-2 adrenoceptor antagonist that activates the central stress response, in a sample of 20 patients receiving opioid replacement therapy (ORT) with buprenorphine/naloxone. The aim of this project was to evaluate the effects of oxytocin on cue-induced opioid craving after yohimbine stress-induction as well as to assess the safety and tolerability of oxytocin and yohimbine in OUD individuals receiving buprenorphine/naloxone. Long term, the goal of this project is to identify the key neuroendocrine pathways that are responsible for stress-induced craving in individuals with opioid use disorder (OUD) in order to inform treatment and improve therapeutic outcomes for this population. The central hypothesis of this proposal is that stress-induced opioid craving will diminish in patients administering oxytocin in addition to ORT. 

Mentor:

Robert Swift, MD, Brown University

Collaborators & Consultants:

Joshua C. Brown, MD, Harvard University 
Sudie E. Back, Ph.D., University of South Carolina
Elinore McCance-Katz, MD, Brown University 

Research Team:

Zoe Brown, MPH, Project Coordinator
Brian Gully, MA, Senior Research Assistant

Brown University School of Public Health
Providence RI 02903 401-863-3375 public_health@brown.edu

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Carolina Haass-Koffler, Ph.D.