Skip to Main Content
Brown University
School of Public Health Brown University

Center for Addiction & Disease Risk Exacerbation

Search Menu

Site Navigation

  • Home
  • About
    • Our Mission
    • CADRE Leadership
    • Contact Us
  • People
    • Core Leaders
    • Investigators
    • Research Team
    • Affiliated Scientists
  • Cores
    • Administrative Core
    • Clinical Lab Core
    • REACH Core
  • Research
    • Research Projects
    • Pilot Projects
    • Supplements
    • Postdocs
  • Funding Opportunities
    • Project Leaders
    • Pilot Projects
    • Postdoctoral Associates
  • News & Events
    • All News
    • Distinguished Visiting Scholars Series
  • Publications
    • Cite CADRE
Search
Center for Addiction & Disease Risk Exacerbation

Hayley Treloar Padovano, Ph.D.

Breadcrumb

  • Home
  • Research
  • Research Projects

Sub Navigation

  • Lauren Micalizzi, Ph.D.
  • Cara Murphy, Ph.D.
  • Alexander Sokolovsky, Ph.D.
  • Elizabeth Aston, Ph.D.
  • Patience Dow, Ph.D.
  • Aditya Khanna, Ph.D.
  • Mollie Monnig, Ph.D.
  • Hayley Treloar Padovano, Ph.D.

Hayley Treloar Padovano, Ph.D.

Biobehavioral Pathways Underlying Alcohol Use Disorder and Alcohol-associated Liver Disease

Project Leader

  • hayley treloar padovano

    Hayley Treloar Padovano, Ph.D.

    Co-Investigator of Team Science Supplement, Fmr. Research Project Lead, Associate Professor of Behavioral and Social Sciences and of Psychiatry and Human Behavior
    hayley_treloar@brown.edu
    Research Profile

Project Status:

Dr. Treloar Padovano graduated as CADRE Research Project Lead after receiving an R01 in 2023. She is currently a Co-Investigator of the Team Science Supplement.

Description:

This study unites a team of addiction scientists and hepatologists for a partnership between the COBRE Center for Addiction and Disease Risk Exacerbation, Brown University Health Hepatology Clinic at Rhode Island Hospital, Providence VA Medical Center, and other Brown University networks, and provides a platform for future work testing AUD interventions integrated with AALD care. The primary aim of this proposal is to demonstrate the feasibility of implementing a brief psychosocial AUD intervention integrated with AALD medical care.

The intervention will include personalized feedback from biomarkers of liver function, drinking patterns, and self-monitoring of craving and negative affect via smartphone reports in daily life. Excessive drinkers (n = 44) consuming >24g/>36g per day, on average, for women/men in the past month, will be recruited from local hospitals, clinics, and the greater community. Half of our participants will have advanced AALD and AUD, and half will have AUD without AALD, with groups matched on drinking level. Recruitment will target equal representation of men and women and oversample for 1/3 individuals of Hispanic ethnicity. The protocol includes a 1-week screening phase, 3-week intervention phase, and 3-month follow-up.

In addition to demonstrating feasibility, this project aims to test whether behavioral endophenotypes associated with alcohol-use outcomes in clinical trials are more resistant to change during AUD intervention for AALD patients with AUD relative to those with AUD only. A final aim is to explore biomarkers of inflammation and immune activation as mechanisms of persistence of endophenotypes, specifically levels of pro-inflammatory cytokines, chemokines, and others implicated in the pathogenesis of AALD.

Mentors:

Peter Monti, Ph.D., Brown University
Kittichai Promrat, MD, Brown University Health
Jessica Mellinger, MD, MSc, University of Michigan

Research Team:

Gabriel Muro, Senior Research Assistant

Brown University School of Public Health
Providence RI 02903 401-863-3375 public_health@brown.edu

Quick Navigation

  • Newsletter
  • Visit Brown
  • Campus Map

Footer Navigation

  • Accessibility
  • Careers at Brown
Give To Brown

© Brown University

School of Public Health Brown University
For You
Search Menu

Mobile Site Navigation

    Mobile Site Navigation

    • Home
    • About
      • Our Mission
      • CADRE Leadership
      • Contact Us
    • People
      • Core Leaders
      • Investigators
      • Research Team
      • Affiliated Scientists
    • Cores
      • Administrative Core
      • Clinical Lab Core
      • REACH Core
    • Research
      • Research Projects
      • Pilot Projects
      • Supplements
      • Postdocs
    • Funding Opportunities
      • Project Leaders
      • Pilot Projects
      • Postdoctoral Associates
    • News & Events
      • All News
      • Distinguished Visiting Scholars Series
    • Publications
      • Cite CADRE
All of Brown.edu People
Advanced Search
Close Search

Hayley Treloar Padovano, Ph.D.