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Center for Addiction & Disease Risk Exacerbation

Elizabeth Aston, Ph.D.

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Elizabeth Aston, Ph.D.

Impact of Acute Cannabis Administration on Pain Symptomology and Inflammatory Markers among Patients with Rheumatoid Arthritis

Project Lead

  • Elizabeth Aston

    Elizabeth Aston, Ph.D.

    Fmr. Research Project Lead, Associate Professor of Behavioral and Social Sciences
    elizabeth_aston@brown.edu
    Research Profile

Project Status:

Dr. Aston's Research Project ended during CADRE Phase I.  Dr. Aston is currently an Associate Professor at the School of Public Health.

Description:

This project will be the first to investigate the impact of cannabis on pain, affect, and markers of inflammation among RA patients. Exploring novel and effective strategies to reduce pain and inflammation among individuals living with RA is crucial as current pharmacotherapies may not completely alleviate negative symptoms, and some, including opioids, pose high dependence liability. We will administer two cannabis formulations via vaporization (placebo and medium THC [1-5%]/medium CBD [1-5%]) across two experimental sessions using a counter-balanced, double-blind, crossover design. Blood will be collected during each session (pre-vaporization, 10 minutes post-vaporization, 60 minutes post-vaporization). Self-reported pain and affect will be assessed at the same time points.

Mentors: 

Jane Metrik, Ph.D., Brown University
Anthony Reginato, M.D., Brown University

Project Collaborator: 

Nancy Shadick, M.D., Harvard Medical School, Consultant

Research Team:

Alexander Gonzalez Trejo, Research Assistant

Brown University School of Public Health
Providence RI 02903 401-863-3375 public_health@brown.edu

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Elizabeth Aston, Ph.D.